This course describes various topics related to the biochemical principles and metabolic pathways with particular emphasis on pharmaceutical applications and biotechnology. This course will focus on the molecular mechanisms of drug action and chemical basis for drug therapy. Current methods used to study medicinal chemistry including recombinant DNA, combinatorial chemistry and bioinformatics, will be reviewed. A 3-D molecular modeling of drug targets and drug design will be integrated throughout the course. Clinical trials of drug case study are included. A term project is incorporated into this course. Students are required to conduct an in-depth review of the literature regarding a topic.